James N Sleigh Selected Research

Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)

5/2013

Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease.

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James N Sleigh Research Topics

Disease

9	Type 2D Charcot-Marie-Tooth disease 04/2024 - 05/2014
7	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 10/2018 - 10/2010
4	Peripheral Nervous System Diseases (PNS Diseases) 04/2024 - 01/2018
2	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 01/2023 - 05/2013
2	Neuromuscular Diseases (Neuromuscular Disease) 10/2021 - 01/2016
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2019 - 04/2014
1	Animal Disease Models 03/2023
1	Frontotemporal Dementia (Semantic Dementia) 11/2019
1	Neuroinflammatory Diseases 11/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2019
1	Muscle Cramp (Cramp) 03/2016
1	Hypoxia (Hypoxemia) 02/2016
1	Nerve Degeneration 05/2014

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 01/2023 - 10/2010
4	Glycine-tRNA LigaseIBA 01/2023 - 05/2014
3	Brain-Derived Neurotrophic Factor (BDNF)IBA 04/2024 - 01/2023
3	Nerve Growth Factors (Neurotrophins)IBA 04/2024 - 01/2023
3	EnzymesIBA 10/2018 - 05/2014
2	Transfer RNA (tRNA)IBA 04/2024 - 03/2024
2	trkB ReceptorIBA 04/2024 - 03/2024
2	Ligases (Synthetase)IBA 04/2024 - 03/2024
2	Nerve Growth Factor Receptors (Neurotrophin Receptors)IBA 01/2023 - 01/2020
1	TropomyosinIBA 01/2023
1	Phosphotransferases (Kinase)IBA 01/2023
1	DNA-Binding Proteins (DNA Binding Protein)IBA 11/2019
1	UbiquitinIBA 10/2018
1	plexinIBA 01/2018
1	Semaphorins (Semaphorin)IBA 01/2018
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017
1	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA 03/2016
1	pimonidazoleIBA 02/2016
1	Peptides (Polypeptides)IBA 01/2016
1	Antisense OligonucleotidesIBA 01/2016
1	OligonucleotidesIBA 01/2016
1	Superoxide Dismutase-1IBA 04/2014
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 05/2013

Therapy/Procedure

5	Therapeutics 03/2023 - 12/2011
3	Denervation 10/2021 - 03/2016
1	Muscle Denervation 11/2019